Spindle cell melanoma (SCM) is a rare morphological subtype of melanoma, which is relatively uncharacterized. The aim of the present study was to investigate the incidence of SCM, its general demographics, basic clinico-pathologic features, treatment outcomes and disease-specific prognostic factors Studies have suggested that between 1% and 14% of melanomas are of the spindle cell variant (including desmoplastic melanoma) [2,3]. Spindle cell melanomas more commonly occur in Caucasian men, affecting men and women at a ratio of 1.6:1-1.9:1 respectively. The average age at diagnosis is 50-80 years [1,4]
Spindle cell melanoma (SCM) is a rare subtype of malignant melanoma composed of spindled neoplastic cells arranged in sheets and fascicles (1). The diagnosis of SCM is challenging, as SCM may occur anywhere on the body and frequently mimics amelanotic lesions, including scarring and inflam-mation (2-4). Histologically, cytologic features of SCM ar For example, if the 5-year relative survival rate for a specific stage of melanoma of the skin is 90%, it means that people who have that cancer are, on average, about 90% as likely as people who don't have that cancer to live for at least 5 years after being diagnosed. Where do these numbers come from The 5-year survival rates for melanoma, according to the American Cancer Society are: Local (cancer has not spread beyond where it started): 99 percent. Regional (cancer has spread nearby/to the. Survival rates. Surviving after being diagnosed with desmoplastic melanoma usually depends on several factors. The main factor is the measured thickness of the melanoma when it was removed surgically. There is an eighty-five percent survival rate of five years and an eighty percent survival rate of ten years. Desmoplastic Melanoma Melanoma cells that pass through the lymphatic system before entering the bloodstream spread and form new tumors more readily than cells that directly enter the bloodstream, a recent study shows. The finding raises the possibility of new treatment approaches that could help keep melanoma from spreading
The survival rates for stage 3 melanoma vary based on the size of the primary tumor and how far the cancer has spread into the lymph nodes and other organs. According to the American Cancer. . There are a lot of factors that could greatly affect the person's chance of survival such as the type of sarcoma, location of the tumor, age of the patient, and the type of treatment received by the patient
Spindle cell melanoma and desmoplastic melanoma differ clinically in prognosis and therapeutic implications; however, because of partially overlapping histopathological features, diagnostic distinction of spindle cell from desmoplastic melanoma is not always straightforward. A direct comparison of d But in advance stage, the prognosis of the treatment becomes narrow, as the vital organ like kidney, lungs or liver may affected. The survival rate is a maximum five years for advance stage spindle cell sarcoma. (2,5 Spindle cell carcinoma generally exhibits a worse prognosis than conventional squamous cell carcinoma. Although reported survival rates vary, one recent study based on epidemiologic data from the United States reported 5-year disease-specific survival of 39% for spindle cell carcinoma of the oral cavity. View chapter Purchase boo
Others with high cellularity and little stroma (best classified as spindle cell melanoma) Small foci of lymphoid aggregates is a useful clue to the diagnosis on scanning May be pure or combined with classic melanoma Desmoplastic neurotropic melanoma considered a variant (33% of all cases of desmoplastic melanoma) (Am J Dermatopathol 2008;30:207 Spindle cell melanoma, that can occur at any site of the body, tend to spread and might be fatal. The prognosis of desmoplastic melanoma is much better, says pathologist Lennerz . Sigal AC, Keenan M, Lazova R Am J Dermatopathol 2012 Apr;34(2):145-50. doi: 10.1097/DAD.0b013e318225b596
Spindle cell melanoma differs from conventional non spindle cell melanomas by a higher propensity for local recurrence and less frequent metastasis to regional lymph nodes at the time of presentation. 5 In one study of 29 patients with spindle cell melanoma (Breslow thickness 1.6 mm to 8 mm), 28 had negative sentinel lymph node biopsies. 10 In. Prognosis Stage 2 Melanoma: With appropriate treatment, Stage II melanoma is considered intermediate to high risk for recurrence or metastasis. The 5-year survival rate as of 2018 for local melanoma, including Stage II, is 98.4%. Click here to learn more about melanoma survival rates. Follow-Up Care for Stage 2 Melanoma Spindle cell melanoma (the cells are longer and tapered at the ends) Epithelioid melanoma (the cells are oval-shaped) Mixed cell melanoma (both spindle and epithelioid) Generally, a tumor made up of spindle cells has a better prognosis than a tumor made up of epithelioid cells. The tumor is given a grade (G) to describe the composition of its. This is not trivial given that such lesions tend to have a better prognosis than conventional, sarcomatoid spindle cell melanomas and melanomas with a combined phenotype (i.e., epithelioid and desmoplastic) at comparable depths of invasion (Figure 23). The natural history of the so-called pure desmoplastic melanoma is that of local recurrence. Melanoma Terms and Definitions • Mixed epithelioid and spindle cell melanoma (8770): Epithelioid melanoma and spindle cell melanoma. Synonyms for In Situ partial regression can be an indicator of poor prognosis. Proven complete regression is very rare; on
Survival of Patients With Primary Pedal Melanoma Susan M. Walsh, DPM,1 Susan G. Fisher, PhD,2 and Ronald A. Sage, DPM3 Malignant melanoma is increasin... Download PDF 699KB Sizes 2 Downloads 49 View Spindle cell melanoma coexisting with chronic lymphocytic leukemia/small lymphocytic lymphoma: a rare collision tumor in multiple sites. Fikret Dirilenoglu MD. skin surveillance of patients with CLL may be important to detect MM at an early stage that correlates with a better prognosis. Open Research The 5-year survival rate for local melanoma is 99 percent. 5. If cancer cells have spread to a nearby lymph node, it is called regional metastasis. In 9 percent of cases, the melanoma has spread to regional lymph nodes at diagnosis. The 5-year survival for regional melanoma is 66.2 percent. 5 The ulcerating tumor is a nodular melanoma, spindle cell variant, which extends deeply into the reticular dermis. Resection margins are not involved by tumor. No radial growth phase is identified. The elongated tumor cells, arranged in streaming fascicles, show
Spindle cells with a vague storiform pattern of DLBCL are not familiar to pathologists. The diagnosis of this condition may be challenging. The differential diagnosis of spindle cell lymphoma of the uterine cervix includes chronic cervicitis, soft tissue sarcoma, spindle cell carcinoma, spindle cell melanoma and dendritic cell tumour Desmoplastic melanoma: it is a fibrosing variant of spindle cell melanoma. the lesions are usually found on the head and neck region and present as bulky firm fibrous masses of tumour or indurated plaques.These are usually amelanotic lesions. Early detection is uncommon. Desmoplasia may be throughout the entire tumor or may be present only in one part of a non-desmoplastic melanoma Melanomas mimic the histologic features of a wide array of tumors including lymphomas, poorly differentiated carcinomas, neuroendocrine tumors, sarcomas and germ cell tumors. 1 Melanoma cells range from epithelioid to spindled and include such diverse cytoplasmic morphologies as clear cell, signet ring shape, rhabdoid, ballooning and plasmacytoid appearance. 1 Melanoma cells form diverse. Pigmented Spindle Cell Nevus (Reed) is a benign, darkly-pigmented skin lesion that chiefly forms on the upper and lower limbs. It is also known as a Reed Nevus or a Reed Tumor. The nevus appears as a single, flat or raised skin lesion that is well-circumscribed. Pigmented Spindle Cell Nevus (Reed) usually occurs in young adults and older children Desmoplastic neurotropic melanoma (DNM) is a rare variant of a spindle cell melanoma . The majority of these tumors occur on the head and neck of elderly patients. The rather variable clinical appearance (e.g. frequent lack of pigmentation) makes initial diagnosis often difficult
Spindle cell sarcoma can affect any age group, but is most common in people over the age of 40. It affects slightly more men than women. Diagnosis We will confirm your diagnosis once we have carried out X-rays, ultrasound and MRI scans (imaging) and have the histology (results) from the biopsy taken from the tumour. The spindle Neurotropic melanoma is a rare subtype of cutaneous malignant melanoma. Compared with conventional melanoma, it is more locally aggressive with an increased tendency for local recurrence but less likely for nodal or distant metastases. These tumours can be a diagnostic dilemma with a variety of morphological, histopathological, and immunophenotypical expressions The earliest stage melanomas are stage 0 (melanoma in situ), and then range from stages I (1) through IV (4). Some stages are split further, using capital letters (A, B, etc.). As a rule, the lower the number, the less the cancer has spread. A higher number, such as stage IV, means cancer has spread more
Spindle cell intraocular melanoma has a better prognosis than epithelioid cell intraocular melanoma or mixed cell intraocular melanoma (this is a mix of both types of cells). Most melanomas of the iris are the spindle cell type so they tend to have a favourable prognosis Malignant melanoma of esophagus is usually a metastatic tumour rather than a primary tumour. Primary malignant melanoma accounts for less than 0.2% of all esophageal neoplasm. We report a case of primary spindle cell malignant melanoma of esophagus in a 69-year-old male who presented with history of dysphagia since 1 month Desmoplastic melanoma (DM)/spindle cell melanoma, although may arise de novo, has the most common association with LM type among all types of melanoma.7 Although hypercellular variants may be noted easily, hypocellular DM is hard to differentiate from scar tissue or a benign dermal spindle cell tumour such as neurofibroma or dermatofibroma
These are spindle and epithelioid. Most melanomas have a combination of these 2 cell types. Only if the eye is removed or the tumor resected can the doctor judge the cell type. Melanomas with predominantly spindle cells have thin elongated cells and imply better prognosis. Epithelioid cell type melanoma has round cells and imply worse prognosis Desmoplastic melanoma (DM) is a rare variant of spindle cell melanoma and an uncommon form of melanoma, comprising 4% of all melanomas. DM was first described by Conley et al. in 1971 as an inconspicuous superficial melanocytic lesion of the head and neck, preceding the development of a bulky dermal and subcutaneous tumor  Cases of spindle cell melanoma (including desmoplastic melanoma), sarcoma of subcutaneous origin, and neuroid sarcoma were excluded. On review, the lesions fell into two categories: (1) those with a definite component of invasive squamous carcinoma in addition to sarcoma-like areas (8 cases), and (2) those in which such a squamous. The five-year survival rate for localized (stage 1 and 2) melanoma is 98 percent; however, this drops to 23 percent in cases where cancer has metastasized to distant sites or organs. (These numbers are based on historical data collected up to 2011, and may change as immunotherapy is more widely used. Although not incorporated into the TNM classification, the cell type of uveal melanomas is also an important prognostic parameter. 6 Melanomas solely composed of spindle cells have a more favorable prognosis than mixed-cell type tumors. Epithelioid cell melanomas are associated with monosomy 3 and class 2 molecular profile, a higher metastatic and mortality rate - and thus displays the worst.
Cutaneous spindle cell squamous carcinoma is an uncommon variant of squamous cell carcinoma, in which (a) keratinocytes infiltrate dermis as single cells with elongated nuclei, not as cohesive nests or islands, and (b) there are no / minimal signs of keratinization of conventional squamous cell carcinoma (Am J Dermatopathol 2008;30:228 Hence, the prognosis for benign melanomas is very good. If the malignant melanomas can be surgically removed before metastasis, the prognosis is good. However, prognosis is poor if the melanoma has had a chance to spread to other parts of the body. Dogs and Spindle Cell Sarcoma Primary ciliary body melanoma arises from melanocytes in the uveal tract. Although uveal melanomas may grow de novo, most develop from a preexisting melanocytic nevus. Three distinct cell types are recognized in uveal melanomas: spindle A, spindle B, and epithelioid Spindle cell melanoma has the best prognosis. Epithelioid is most likely to spread, whilst mixed cell melanomas have an intermediate behaviour. Of note, the size and position of the tumour also affects the prognosis of individual melanomas. Uveal melanomas can invade locally within the eye, and form deposits in other organs, but most commonly.
Secondary colon cancers in person with melanoma are associated with far shorter survival times (an average of 10 months) due primarily to late diagnosis. According to a study from the Mayo Clinic, the average time between diagnosis of the primary melanoma and the secondary colon cancer was an astonishing 7.47 years Generally accepted variables estimating the prognosis for uveal melanoma include: the patient's age, the size of the tumor, the cell type seen on histology (spindle A cells associated with the best prognosis and epithelial cells the worst), histological characteristics (meiotic activity, lymphocytic infiltration, fibrovascular loops) the. To assign a stage to your melanoma, your doctor will: Determine the thickness. The thickness of a melanoma is determined by carefully examining the melanoma under a microscope and measuring it with a special tool. The thickness of a melanoma helps doctors decide on a treatment plan. In general, the thicker the tumor, the more serious the disease
Choroidal melanoma. Histologic section showing spindle B cells in a uveal melanoma. Epithelioid melanoma cells are highly anaplastic, poorly cohesive, and have considerable morphologic variation. In the 16 cats with intraocular melanoma, neoplasms were classified as mixed cell (eight), epithelioid (six), and spindle cell (two), based on previously described characteristics (Figs. 1-4).6,21 The amount of pigmen- tation, hemorrhage, and necrosis varied from tumor to tumor and in different areas of the same tumor . It's sort of like all bets are off, and we have to go full force
Desmoplastic melanoma (DM) is first described by Conley et al in 1971 as a cutaneous tumor exhibiting similar clinical and histological patterns as invasive fibrous tumors, but with distinct morphological characteristics. 1 At present, DM is considered to be a variant of spindle cell melanoma, accounting for less than 4% of all types of melanoma . Fibrosarcoma and spindle cell tumors originate in the connective tissues of the skin and beneath the skin. This will help them give your dog an accurate prognosis and. Melanoma is the most serious form of skin cancer. In the United States, it is the fifth most common cancer in men and women [ 1 ]; its incidence increases with age. As survival rates for people with melanoma depend on the stage of the disease at the time of diagnosis, early diagnosis is crucial to improve patient outcome and save lives
spindle cell carcinoma Carcinosarcoma, pseudosarcoma An aggressive and poorly differentiated carcinoma composed of sweeping fascicles of elongated epithelial cells of transitional, squamous, undifferentiated or rarely glandular origin that mimics a sarcoma clinically and pathologically; SCCs are most common in the oral cavity-♂:♀ ratio, 10:1, and a variant of squamous cell carcinoma; it. Melanoma, also redundantly known as malignant melanoma, is a type of skin cancer that develops from the pigment-producing cells known as melanocytes. Melanomas typically occur in the skin but may rarely occur in the mouth, intestines or eye (uveal melanoma).In women, they most commonly occur on the legs, while in men they most commonly occur on the back Clear Cell Sarcoma of Soft Tissue: A Detailed Review. An ESUN Article by Garrett Barry and Torsten O. Nielsen, MD, PhD Also available in Chinese, French, Portuguese and Spanish. Introduction. Clear cell sarcoma of soft tissue, formerly known as malignant melanoma of soft parts, is a poor prognosis neoplasm primarily affecting young adults between twenty and forty years of age. 1 This tumor is. There appears to be a morphologic continuum between desmoplastic melanoma and vertical growth phase spindle cell melanoma, the latter being the most frequent type of invasive melanoma seen in. Spindle cell nevi. Spindle cell melanoma. Necrotic melanoma. Epitheloid cell melanoma. Mixed cell melanoma. The epitheloid cell and the mixed cell melanoma have the poorest prognosis among all the subtypes . Immunohistochemical markers characteristic of choroidal melanoma are S-100, HMB-45
The melanoma histologic subtypes in the CMM category included superficial spreading, nodular, lentigo maligna, balloon cell, amelanotic, desmoplastic, mucosal lentiginous, mixed epithelioid/spindle cell, epithelioid, and spindle cell melanomas. Tumors designated as ALM were not included in the CMM category It has been suggested [4, 5] that animals with melanoma of the foot have a worse prognosis than those with similar tumours in other skin sites. A study ofthe response ofcanine melanomas to therapy may be ofvalue in the epithelioid and spindle cell type; and 4) dendritic and whorled type Lesions can contain spindles cells, epitheloid cells, or both. Spindle cell melanomas have the best prognosis, epithelioid cell melanomas have the least favorable prognosis, and mixed-cell melanomas have an intermediate prognosis (9). Tumors made entirely of spindle A cells are nevi Metastatic melanoma life expectancy. The 5-year survival rate for a metastatic melanoma is about 15% to 20% 7).The 10-year survival is about 10% to 15% 8).The outlook is better if the spread is only to distant parts of the skin or distant lymph nodes rather than to other organs, and if the blood level of lactate dehydrogenase (LDH) is normal
Conley J, Lattes R, Orr W: Desmoplastic malignant melanoma (a rare variant of spindle cell melanoma). Cancer 28:914-936, 1971. 34. Austin PF, Cruse W, Lyman G, et al: Age as a prognostic factor in the malignant melanoma population. Ann Surg Oncol 1:487-494, 1994. 35 The important diagnostic issues include (1) distinguishing spindle cell squamous cell carcinoma and malignant melanoma from true sarcoma, (2) discriminating between benign spindle cell lesions and malignancies, and (3) classifying histologic types and subtypes. 5 The commonly used immunohistochemical markers for differential diagnosis of. When I shared with you last month that the results of my biopsy came back as stage IIa Spindle Cell Melanoma and that seeing a surgeon was my next step. I think I should show you a photo of what that original melanoma looked like on my skin. It's nothing like what is shown online or in doctors offices of what melanoma looks like
Hi I am new to the site and found out today that I have spindle cell melanoma and of course I am quite anxious. My cancer is stage 1b which I think is 'early' stages. A question really - the consultant was very good today and I was referred to a specialist nurse and had a long chat about the treatment I will have but as always after I came away. Rare subtypes: mucosal melanoma, desmoplastic melanoma, nevoid melanoma; Breslow Depth: The Breslow's depth of invasion is a measurement of the thickness of a melanoma, at its thickest point, in millimeters. This measurement is an important factor in prognosis. For example, a thicker melanoma has a poorer prognosis
Olsen et al. reported 34 cases with laryngeal and hypopharyngeal spindle cell carcinoma; recurrence occurred in 10 cases and the 3-year survival rate was 56.8%. In Su et al.'s series, the overall survival rate of oral spindle cell carcinoma was 27.5% over 3 years. The survival rate in our case was 12 months, which might be due to its late. Three distinct cell types are recognized in choroidal and other uveal melanomas: (1) spindle A, (2) spindle B, and (3) epithelioid. The last cell type usually has the most aggressive behavior and carries a poorer prognosis for the patient's long-term survival On December 23, my doctor took a biopsy and three days later I had a diagnosis of Spindle Cell Melanoma, a rare subtype of malignant melanoma. He advised that I get to a specialist immediately as it was large and very deep and needed to be acted on quickly. In 2014, that diagnosis had a very poor prognosis. My doctor said my best chance was. Finally, poorly differentiated/spindle cell squamous cell carcinoma (SCC) or metaplastic SCC may be misinterpreted as melanoma with divergent epithelial transdifferentiation, however, evidence of.
Spindle Cell Tumor. lynnmf. Posts: 2. Joined: Sep 2005. Sep 22, 2005 - 4:21 pm. On Sept 2 a tumor was found in my abdomen. On the 9th I had surgery and was told that a soccer ball sized tumor was removed from my abdomen. It had been attached to the omentum. They also did a complete hysterectomy - for other reasons Mean survival was 20+/-23. 46 (1-84) months. Average diameter of the resected tumours was 5. 43+/- cm (1. 3-10 cm). Most tumours had epithelioid or spindle cell morphology, were positive for one or more melanocytic markers (S100, HMB-45 or MITF). More than half of tumours had no or very little melanin pigment Several pathologic features correlate with prognosis: Spindle cell melanomas have the best prognosis, followed by mixed cell lesions. Epithelioid cell lesions generally have the worst prognosis. Size smaller than 10 mm in greatest dimension and the absence of extrascleral extension confer a better prognosis than larger lesions This manuscript provides an overview of pleomorphic spindle cell tumors presenting on sun-damaged skin of the elderly and includes discussions of atypical fibroxanthoma, pleomorphic dermal sarcoma, spindle cell and metaplastic squamous cell carcinoma, spindle cell and dedifferentiated melanoma and poorly differentiated cutaneous angiosarcoma. These tumors share many of the clinical presenting. Melanoma is a rare malignancy in childhood such that only 0.3 to 0.4% of all melanomas develop in prepubertal children. Spindle cell melanoma accounts for only 3 to 14% of all melanomas. The authors report here a case of spindle cell melanoma in Because of the aggressive nature of spindle cell mesothelioma, cancer tends to return relatively soon, even after extensive surgery. Sarcomatoid is the most aggressive and fastest spreading mesothelioma cell type and has the lowest average survival rate. It makes up 10% to 20% of all mesothelioma cases